News Oct 29, 2026
Redesigned microscope records single neurons two millimeters deep in the living mouse brain
Researchers at The Rockefeller University have rebuilt a three-photon microscope from the ground up, allowing them to watch the activity of individual neurons up to about 2.1 millimeters deep in the brains of living mice, without surgically removing the tissue above. The new platform, called TrUDI, opens deep brain regions such as the hippocampus and striatum to optical imaging while staying within safe heating limits.
Giulio Prisco 2 min read