0 Comments

0 thoughts on “Scientists find way to wipe a cell’s memory to better reprogram it as an embryonic stem cell

back Back

Scientists find way to wipe a cell’s memory to better reprogram it as an embryonic stem cell

Aug. 16, 2023.
1 min. read Interactions

New "TNT" method mimics the reset of a cell’s epigenome that happens in very early embryonic development

About the Writer

Amara Angelica

84.37234 MPXR

Amara Angelica is Senior Editor of Mindplex

Human iPS cells (credit: Jia Tan, Polo laboratory)

In a groundbreaking study published in the journal Nature today (Aug. 16, 2023), Australian scientists say they have developed a new method to reprogram human cells, better mimicking embryonic stem cells, with significant implications for biomedical and therapeutic uses.

Called “transient-naive-treatment (TNT) reprogramming,” the method mimics the reset of a cell’s epigenome that happens in very early embryonic development, and it addresses a long-term problem in regenerative medicine.

“We need stem cells to replace our old cells, which are capable of only a limited number of replications,” explained Dr. Deborah Duong, CTO of Rejuve.AI and an AI researcher for Singularity Net. “However, the amount of stem cells we have decreases as we age. So this could be part of an answer, but there is still a long way to go.”

The research is led by Professor Ryan Lister from the Harry Perkins Institute of Medical Research and The University of Western Australia and Professor Jose M. Polo from Monash University and the University of Adelaide.

Citation: Sam Buckberry et al. Aug. 16, 2023. Transient naive reprogramming corrects hiPS cells functionally and epigenetically. Nature /s41586-023-06424-7 (open-access)

Let us know your thoughts! Sign up for a Mindplex account now, join our Telegram, or follow us on Twitter

Like
Dislike
Share
0 Comments
Reactions
💯 💘 😍 🎉 👏
🟨 😴 😡 🤮 💩

Here is where you pick your favorite article of the month. An article that collected the highest number of picks is dubbed "People's Choice". Our editors have their pick, and so do you. Read some of our other articles before you decide and click this botton; you can only select one article every month.

People's Choice
Bookmarks