back Back

Sugar substitute xylitol linked to increased risk of heart attack and stroke

Jun. 12, 2024.
2 min. read Interactions

Common sugar substitute 

About the writer

Amara Angelica

198.01421 MPXR

Health fan

Xylitol (credit: AJMC)

Cleveland Clinic researchers have found higher amounts of the sugar alcohol xylitol are associated with an increased risk of cardiovascular events like heart attack and stroke.  

The team, led by Stanley Hazen, M.D., Ph.D., found an association in a large-scale patient analysis, preclinical research models and a clinical intervention study. Findings were published in the European Heart Journal  

Xylitol is a common sugar substitute used in sugar-free candy, gums, baked goods and oral products like toothpaste. Over the past decade, the use of sugar substitutes has increased significantly in processed foods that are promoted as healthy alternatives, said Hazen in a statement.

Investigating sugar alcohols and artificial sweeteners

“This study again shows the immediate need for investigating sugar alcohols and artificial sweeteners, especially as they continue to be recommended in combatting conditions like obesity or diabetes,” said Dr. Hazen, Chair of Cardiovascular and Metabolic Sciences at Cleveland Clinic’s Lerner Research Institute and Co-Section Head of Preventive Cardiology in the Heart, Vascular & Thoracic Institute.

Xylitol is a sugar substitute commonly used in sugar-free candy, gums, baked goods, and oral products like toothpaste. The use of sugar substitutes has increased significantly in processed foods as these products have been promoted as healthier alternatives to sugar.

Research limitation: association, not causation

The authors note that further studies assessing the long-term cardiovascular safety of xylitol are warranted. The research had several limitations, including the fact that the studies demonstrate association and not causation. They recommend talking to your doctor or a certified dietitian to learn more about healthy food choices and for personalized recommendations.   

The study was partly supported by the National Institutes of Health and the Office of Dietary Supplements.

Citation: Marco Witkowski, Ina Nemet, Xinmin S Li, Jennifer Wilcox, Marc Ferrell, Hassan Alamri, Nilaksh Gupta, Zeneng Wang, Wai Hong Wilson Tang, Stanley L Hazen, Xylitol is prothrombotic and associated with cardiovascular risk, European Heart Journal, 2024, ehae244, https://doi.org/10.1093/eurheartj/ehae244

Let us know your thoughts! Sign up for a Mindplex account now, join our Telegram, or follow us on Twitter

Comment on this content

0 Comments

0 thoughts on “Sugar substitute xylitol linked to increased risk of heart attack and stroke

Like

Dislike

Share

Comments
Reactions
💯 💘 😍 🎉 👏
🟨 😴 😡 🤮 💩

Here is where you pick your favorite article of the month. An article that collected the highest number of picks is dubbed "People's Choice". Our editors have their pick, and so do you. Read some of our other articles before you decide and click this button; you can only select one article every month.

People's Choice
Bookmarks