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Accelerated wound-healing ink uses 3D-printing pen

Jun. 02, 2023.
1 min. read 6 Interactions

Repaired mice wounds in just 12 days

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Amara Angelica

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Amara Angelica is Senior Editor, Mindplex

3-D printing pen prints gel that can help wounds of all shapes heal quickly and effectively (credit: ACS Applied Materials & Interfaces)

Researchers in China and Singapore have developed a wound-healing ink that can actively encourage the body to heal. The ink can be spread into a cut of any shape using a standard 3D-printing pen. In mice, the technology nearly completely repaired wounds in just 12 days.

This method accelerates the natural healing process, in which extracellular vesicles (EVs) secreted from white blood cells play important roles in promoting blood vessel formation and reducing inflammation during healing.

PAINT treatment process

(credit: ACS Applied Materials & Interfaces)

The team developed a system called PAINT (portable bioactive ink for tissue healing) using EVs secreted from macrophages combined with sodium alginate. These components were combined in a 3D-printing pen, mixing at the pen’s tip and forming a sturdy gel at the site of injury within three minutes.

The EVs promoted blood vessel formation and reduced inflammatory markers in human epithelial cells, shifting them into the “proliferative” (growth) phase of healing.

Citation. Paintable Bioactive Extracellular Vesicle Ink for Wound Healing. ACS Appl. Mater. Interfaces 2023, 15, 21, 25427–25436. May 19, 2023. DOI: 10.1021/acsami.3c03630

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One thought on “Accelerated wound-healing ink uses 3D-printing pen

  1. As wound-healing is a relatively quick and easily observable process, I would expect to see increasingly more effort and AI driven progress in that area in the near future.
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