Microsoft Confirms Its $10 Billion Investment Into ChatGPT, Changing How Microsoft Competes With Google, Apple And Other Tech Giants

Microsoft’s recent investment in OpenAI, the company behind the AI-powered chatbot ChatGPT, is a strategic move that places the tech behemoth at the cutting edge of generative artificial intelligence. The $10 billion investment will power the workloads of research, products, and API services, as well as extend Microsoft’s partnership with OpenAI. Microsoft Azure will continue to be the startup’s sole cloud provider, despite its $29 billion valuation. This investment comes at a time when Microsoft is cutting 10,000 jobs globally while also investing heavily in AI-based technology. The AI-powered chatbot, which already has one million users after only a few months, has the potential to change the AI landscape and be the “iPhone moment” for the field.

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Google is testing a new AI model called MusicLM, which can generate “high-fidelity music from text descriptions”.

Google’s new artificial intelligence system, MusicLM, can compose music in any genre based on a written description. This system is one of a kind because of its capacity to produce high-quality, cohesive music that is both highly complex and capable of building on preexisting tunes. MusicLM can also create tunes based on specific parameters such as location, time period, and mood. For the purpose of learning to create music, the system was exposed to a whopping total of 280,000 hours of music throughout its training phase. Some of the system’s samples are distorted, and there are problems with the created vocals, despite its amazing capabilities. Ethical issues, such as the possible infringement of copyright, were also brought up by the researchers.

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Generative AI like viral ChatGPT lands on DISA technology watch list

Defense Information Systems Agency (DISA) authorities in the United States have taken note of ChatGPT, a bot developed by OpenAI that generates natural-sounding material using AI. DISA’s watch list, which is frequently updated to include areas that have become critical to defense connectivity and security, now include ChatGPT. The U.S. military has been investing in artificial intelligence and related technologies to enhance battlefield analysis and maintenance forecast, although the precise application of generative AI in the Pentagon yet to be seen. From $600 million in 2016, public investment in AI at the Pentagon has climbed to $2.5 billion in 2021, and by early 2021, more than 685 AI projects had been initiated. While ChatGPT has the potential to increase efficiency in the workplace, it is not without its critics who raise concerns about potential prejudice and ethical issues.

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Watch Out, Software Engineers: ChatGPT Is Now Finding, Fixing Bugs in Code

According to a new study by computer science researchers from Johannes Gutenberg University Mainz and University College London, OpenAI’s ChatGPT outperformed existing AI systems in fixing software bugs. ChatGPT solved 31 of 40 problems with buggy code, while Codex, CoCoNut, and Standard APR solved 19, 19, and 7 problems, respectively. ChatGPT’s main advantage is its ability to converse with humans, allowing it to request more information and increase its success rate. The research has the potential to upend the $600 million bug-fixing software industry. However, because ChatGPT is a public database, it may be difficult for tech companies to adopt it in its current form. The impact of ChatGPT on software development in the future remains to be seen.

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How Google’s AI tool Sparrow is looking to kill ChatGPT

Sparrow AI is a new language model developed by Google that could potentially replace existing tools such as ChatGPT. The ability of Sparrow to understand context and perform multiple NLP tasks with a single model is its key advantage. This increases its versatility and efficiency over ChatGPT, which is primarily used for text generation and language modeling. Sparrow has the potential to become a popular choice in the near future due to its efficient training and improved safety features. It is important to note, however, that there may be biases and political battles over its sources and how it links to information. Sparrow, on the other hand, is a powerful tool with improved NLP capabilities that is worth keeping an eye on as it is set to be released for limited testing in 2023.

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The search for a habitable Earth 2.0

In about 5 billion years, the Sun is due to turn into a red giant. But long before then, there are other concerns, such as asteroids, global warming, and nuclear destruction.

So there’s a long-range quest to find planets that orbit stars other than the Sun, referred to as “Earth 2.0.” As conceived by NASA, Earth 2.0 would be a habitable planet similar enough to Earth , intended to enable the existence of life as we know it. Assuming we could somehow get there, we would also require a “habitable zone” that:

  • Is similar enough to Earth to enable existence of life as we know it.
  • Is the right temperature for liquid water
  • Orbits a nearby star with a steady supply of light.
  • Ideally, is close enough that we could imagine going there or at least sending a probe to explore it.

Researchers at Rensselaer Polytechnic Institute have just received a grant from NASA to find out how. Or at least, find all such habitable-zone planets closer than 10 parsecs, or 192 trillion miles, the range of our technology. The researchers are leading a team in pursuit of an idea that could make it possible to find nearby, habitable, Earth-like planets — or prove that they are unlikely to exist.

Heidi Jo Newberg, professor of physics, applied physics, and astronomy at Rensselaer, has been named a NASA Innovative Advanced Concepts (NIAC) Program Fellow. She will join a prestigious group of innovative scientists whose visionary ideas have included new types of space propulsion systems, robots that are modeled after nature such as spiderbots, and technology that makes it easier for humans to live in space.

Three times the diameter of the James Webb Space Telescope — range: 192 trillion miles

“Dittoscope” ("Diffractive Interference Coronagraph Exoplanet Resolver") (or DICER) telescope,
The DICER telescope could find all habitable zone planets closer than 192 trillion miles (credit: Rensselaer Polytechnic Institute)

The key technology, designed by Thomas D. Ditto, inventor of the “Dittoscope” (“Diffractive Interference Coronagraph Exoplanet Resolver” or DICER) telescope, would be three times the diameter of the state-of-the-art James Webb Space Telescope. It’s designed to find all habitable zone planets closer than 10 parsecs, or 192 trillion miles.

Thomas Ditto, inventor of the Dittoscope (DICER)

“With DICER, light from a faint planet would be collected by two 10-meter diffraction gratings, which are easier to pack up in a rocket to shoot into space than a telescope with conventional mirrors and lenses,” Ditto explained. “DICER uses a diffraction grating primary objective and that changes everything.”

To determine whether conditions on a planet are right for life or whether it has already started to develop, scientists look at the air that surrounds the planet. But DICER may even be able to detect if the newly discovered exoplanets have atmospheric ozone, a biomarker that may indicate the existence of life as we know it.

Is all this feasible?

“Nobody really knows,” Newberg says. “We could find zero or we could find 100 habitable exoplanets. But the discovery of even one oxygen-rich, terrestrial exoplanet in the local neighborhood of our own Sun would be among the most publicly engaging astronomical results of all time!

“The DICER technology is also scalable, so the potential exists to find exoplanets that are fainter or farther away in the future. So far, most exoplanets have been found because they pass in front of their host star and block some of its light, but DICER could find exoplanets that orbit in any orientation.”

Newberg and her doctoral student Leaf Swordy will collaborate with Shawn Domagal-Goldman and Richard K. Barry, astronomers at NASA Goddard Space Flight Center; and L and Frank Ravizza, optical engineers at Lawrence Livermore National Laboratory.

Update January 31:

Comments by legendary science-fiction author and astronomer Dr. David Brin sent to Mindplex

I doubt NASA wants to be directly cited as fostering notions of interstellar colonization.

1. Because of the distances … the nearest such world (if they exist at all) … would be a million times farther than NASA’s greatest current ambition.

2. A popular expression is “there is no Planet B.” If you talk about a backup world to Earth, you risk being denounced as someone willing to give up on saving Planet A.

I’d rewrite the opening to emphasize that.

While it is both fun and enthralling to speculate about our descendants someday crossing the vast interstellar gulfs to other habitable worlds, that is not the central goal of scientific campaigns to seek “Earthlike planets” out there.  No such world can ever serve as a “Planet B” to escape from our duties, here in the Solar System. Still NASA and the European Space Agency and others have prioritized the search for life-bearing worlds circling other stars, in part because of great public and scientific interest. But another motive must be to gain information about alien ecosystems — both their similarities and differences — which might improve our models and our planetary management, here at home.

David Brin

www.davidbrin.com

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Got insomnia? You may want to listen to your brain with an ‘acoustic mirror’

A good night’s sleep is crucial to health and wellbeing. Numerous research studies have shown that insomnia can increase the risk of cardiovascular events, obesity, diabetes and other illnesses. 

Now a new study by researchers at Wake Forest University School of Medicine has shown significant improvements in both sleep quality and improved autonomic nervous system function, using closed-loop, acoustic-stimulation neurotechnology.

How to listen to your brain

Invented by Scottsdale, Arizona-based Cereset, the idea is to monitor your brainwaves using EEG scalp sensors, then use software algorithms to translate specific brain frequencies into audible tones of varying pitch*. These tones, synchronized with the brain waves, are echoed back in real time via earbuds. In effect, this lets your brain listen to itself.

This “Cereset Research with Standard Operating Procedures” (CR-SOP) method (an improvement to HIRREM) “allows the brain to reset from stress patterns that contribute to insomnia, says Charles H. Tegeler, M.D., chair of neurology at Wake Forest University School of Medicine. “During the intervention, the brain continuously updates with respect to its own activity patterns, resulting in auto-calibration or self-optimization,” he explained.

Clinically significant improvements

To assess this method, Tegeler led a new study, published in Global Advances in Integrative Medicine and Health, an open-access journal.

In a randomized and controlled study of 22 adults, researchers compared changes on the Insomnia Severity Index (ISI), a self-report instrument to assess insomnia symptoms. Subjects in the CR-SOP group reported reduced insomnia symptoms. They also showed statistically and clinically significant improvements in autonomic function across multiple measures such as heart rate variability (HRV) and baroreflex sensitivity (BRS), compared to those who received random tones.

The core brain-mirroring technology is now available in 58 local Cereset client centers in the US, according to the company. Hopefully, this ingenious tech can help stressed-out folks, such as Covid healthcare workers and caregivers.

* Hmmm, could this allow for creating music with your mind? (Paging Jam Galaxy!)

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Anti-aging gene shown to rewind heart age by 10 years in centenarians

Single administration halts decay

An anti-aging gene discovered in a population of centenarians has been shown to rewind the heart’s biological age by 10 years, offering a potential target for patients with heart failure.

The gene was discovered by scientists at the University of Bristol and the MultiMedica Group in Italy, and funded by the British Heart Foundation and the Italian Ministry of Health. The study was published in the journal Cardiovascular Research.

Carriers of healthy mutant genes, like those living in blue zones of the planet, often live to 100 years or more and remain in good health. These individuals are also less prone to cardiovascular complications. Scientists believe the gene helps to keep their hearts young by protecting them against diseases linked to aging, such as heart failure.

In this new study, researchers demonstrate that one of these healthy mutant genes, previously proved particularly frequent in centenarians, can protect cells collected from patients with heart failure requiring cardiac transplantation.

Single administration halts decay of heart function in elderly mice

The Bristol team, led by Professor Paolo Madeddu, has found that a single administration of the mutant anti-aging gene halted the decay of heart function in middle-age mice. Even more remarkably, when given to elderly mice, whose hearts exhibit the same alterations observed in elderly patients, the gene rewound the heart’s biological clock age by the human equivalent of more than ten years.

Professor Madeddu, Professor of Experimental Cardiovascular Medicine from Bristol Heart Institute at the University of Bristol and one of the study’s authors, explained: “The heart and blood vessel function is put at stake as we age. However, the rate at which these harmful changes occur is different among people. Smoking, alcohol, and sedentary life make the aging clock faster. Whereas eating well and exercising delay the heart’s aging clock.

Healthy gene found in centenarians could be transferred to unrelated people to protect their hearts

“In addition, having good genes inherited from parents can help to stay young and healthy. Genes are sequences of letters that encode proteins. By chance, some of these letters can mutate. Most of these mutations are insignificant; in a few cases, however, the mutation can make the gene function worse or better, like for the mutant anti-aging gene we have studied here on human cells and older mice.”

Monica Cattaneo, a researcher of the MultiMedica Group in Milan, Italy, and first author of the work, said: “The cells of the elderly patients, in particular those that support the construction of new blood vessels, called ‘pericytes’, were found to be less performing and more aged. By adding the longevity gene/protein to the test tube, we observed a process of cardiac rejuvenation: the cardiac cells of elderly heart failure patients have resumed functioning properly, proving to be more efficient in building new blood vessels.”

Electron microscopy showed laminated bodies in pericytes about a capillary (Credit: Wikimedia Commons)

Centenarians pass their healthy genes to their offspring. The study demonstrates for the first time that a healthy gene found in centenarians could be transferred to unrelated people to protect their hearts. Other mutations might be found in the future with similar or even superior curative potential than the one investigated by this research. Professor Madeddu and Professor Annibale Puca of the MultiMedica Group believe this study may fuel a new wave of treatments inspired by the genetics of centenarians. 

Clinical trials

Professor Madeddu added: “Our findings confirm the healthy mutant gene can reverse the decline of heart performance in older people. We are now interested in determining if giving the protein instead of the gene can also work. Gene therapy is widely used to treat diseases caused by bad genes. However, a treatment based on a protein is safer and more viable than gene therapy.

“We have a new confirmation and enlargement of the therapeutic potential of the gene/protein, says Annibale Puca, Head of the laboratory at the IRCCS MultiMedica and Professor at the University of Salerno. “We hope to test its effectiveness soon in clinical trials on patients with heart failure.”

Paper: The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy by Annibale Puca et al. in Cardiovascular Research [open access]

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Ripples in the fabric of the universe may reveal the start of time

Possible light generated by gravitational waves (credit: L. Rezolla (AEI) & M. Koppitz (AEI & Zuse-Institut Berlin)

Gravitational waves can peer back to the beginning of everything we know, say researchers.

“We can’t see the early universe directly,” but maybe we can see it indirectly if we look at how gravitational waves from that time have affected matter and radiation that we can observe today,” said Deepen Garg, lead author of a paper reporting the results in the Journal of Cosmology and Astroparticle Physics.

Garg and his advisor Ilya Dodin, who is affiliated with both Princeton University and PPPL, adapted this technique from their research into fusion energy, the process powering the sun and stars that scientists are developing to create electricity on Earth without emitting greenhouse gases or producing long-lived radioactive waste. Fusion scientists calculate how electromagnetic waves move through plasma, the soup of electrons and atomic nuclei that fuels fusion facilities known as tokamaks and stellarators

It turns out that this process resembles the movement of gravitational waves through matter. “We basically put plasma wave machinery to work on a gravitational wave problem,” Garg said.

Garg and Dodin created formulas that could theoretically lead gravitational waves to reveal hidden properties about celestial bodies, like stars that are many light years away. As the waves flow through matter, they create light whose characteristics depend on the matter’s density.

A physicist could analyze that light and discover properties about a star millions of light years away. This technique could also lead to discoveries about the smashing together of neutron stars and black holes, ultra-dense remnants of star deaths. They could even potentially reveal information about what was happening during the Big Bang and the early moments of our universe.

This research was supported by the U.S. National Science Foundation through Princeton University.

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Will connectomics and machine intelligence map the brain?

We’ve all seen a microscopic image of neurons in the brain. But this image is misleading: Neurons don’t exist in isolation in the human brain. Some 86 billion neurons form 100 trillion connections to each other.

To make sense of these connections, Wei-Chung Allen Lee, Harvard Medical School associate professor of neurology at Boston Children’s Hospital, is working in a field of neuroscience called connectomics, which aims to comprehensively map connections between neurons in the brain. It’s a convergence of neurobiology, engineering, computing power and artificial intelligence.

“The brain is structured so that each neuron is connected to thousands of other neurons, and so to understand what a single neuron is doing, ideally you study it within the context of the rest of the neural network,” says Lee.

A map of the brain

To do that, Lee and associates are trying to couple connectomics with recordings of neural activity to do what they call “functional connectomics.” “Essentially, we take the map of where every neuron is and how it is connected to every other neuron, and we layer on information about the activity of those neurons in a living animal.

”We are also using genetic engineering approaches to label specific cell types, which is additional information that we can layer on top of connectivity.”

What do you see when you turn out the light (and fall asleep)?

“Some have argued that you are your connectome. When you fall asleep at night, your brain activity dramatically changes, interrupting your thoughts and feelings — but when you wake up, you resume your thoughts and feelings without any break in your sense of self.

”This is likely because your brain connectivity has remained largely intact through the night. In essence, the structure of how our neurons are wired is our ‘self,’ and connectomics is the key to understanding this structure.”

Machine learning meets connectomics

The researchers are developing and applying high-throughput microscopy, computational approaches, and machine learning to generate connectomes and translate these detailed maps of neural connectivity into biological and computational insights.

”We have mainly worked with mice and fruit flies, which are powerful and well-studied model systems,” said Lee. “The field has sophisticated genetic tools that allow us to label different populations of neurons across the central nervous systems of these species. In fruit flies, we can use the technologies we’ve been developing for connectomics to capture the entire brain and nervous system at synapse resolution.”

“In the mouse, we can target relevant neural circuits or subcircuits.” The researchers are using these models to study the basic principles of how neural circuits are built and operate — basically how the brain’s neural networks are connected to each other to perform different computations that underlie behavior.”

One key component of their approach is serial transmission electron microscopy, or EM, which has unsurpassed spatial resolution, signal-to-noise ratio, and speed relative to other serial EM methods. This technique allows them to identify excitatory and inhibitory neurons, as well as the synapses, or small gaps where neurons connect to each other. They can also examine connectivity patterns of neurons, and study the organization of synaptic connections.

Reference: Nguyen, T.M., Thomas, L.A., Rhoades, J.L. et al. Structured cerebellar connectivity supports resilient pattern separation. Nature 613, 543–549 (2023). https://doi.org/10.1038/s41586-022-05471-w

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